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Initial studies demonstrated that although mature erythrocytes contain procaspase-3 and procaspase-8, they are devoid of the mitochondrial apoptotic machinery, e.g., APAF-1, cytochrome c, and caspases-2, -6, -7, and -9 [22, 23]

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By 2005, the first GLP-1 medication gained FDA approval in the U.S

In addition, our study highlights the importance of screening unaffected family members alongside affected individuals, as this strategy can help assess the pathogenicity of a variant even in cases where functional characterization is unavailable

This is important because patients who respond early to antipsychotic treatment not only feel better sooner, they also do better in the long term