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Furthermore, LA modulates immune cell function

Outcomes of interest for this review included cellular factors such as neurotrophins (i.e., brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1)) and inflammatory markers, hemodynamic and functional measures for any cerebral conduit arteries (e.g., neck artery compliance/stiffness, blood flow, reactivity) and cerebral arteries (e.g., cerebral hemodynamics, blood flow, reactivity, autoregulation), brain structure (regional grey matter integrity, white matter lesions, diffusion tensor images, blood-brain barrier (BBB) integrity), clinical neurodegenerative measures (amyloid deposition, tau neurofibrillary tangles, inflammatory markers), functional connectivity (functional magnetic resonance imaging (fMRI) indices), and cognitive function

Patients randomized to exenatide started on a dose of 5 mcg twice-daily for 4 weeks and then were escalated to 10 mcg twice daily

Russo A, Stevens JE, Chen R, Gentilcore D, Burnet R, Horowitz M, et al

AstraZeneca is preparing to file for an FDA approval of its investigational blood pressure pill baxdrostat by 2025-end, with launches targeted for 2026