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Brown RB, Tozer DJ, Loubire L, Harshfield EL, Hong YT, Fryer TD, et al

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Glucagon receptor-mediated effects introduce additional considerations: Potential for transient increases in heart rate (also observed with GLP-1R agonists) Theoretical risk of hyperglycaemia from glucagon signalling, though phase 2 trial data suggest this is counterbalanced by concurrent GLP-1R and GIPR agonism In phase 2 trials, the most commonly reported adverse events were gastrointestinal in nature, consistent with the class

In this article, well break down how they work, their benefits, potential side effects, and key differencesso you can make an informed choice about berberine vs semaglutide