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Thanks for sharing this nuanced perspective, Peter Attia As a growing body of evidence highlights the vital role of lean mass in health span and longevity, do you think theres any hope for body composition to be mandated as a primary endpoint at some point in the future for trials of obesity and weight management therapies

Effective treatments may depend on the extent of lung injury and require a multi-faceted pharmacological approach

For example, phosphorylation of signal transducer and activator of transcription 3 (STAT3) at Ser727 has been shown to be an important node through which toll-like receptor 4 (TLR4) mediates metabolic reprogramming and promotes IL-1 production, thereby providing a new mechanistic entry point for integrating receptor signaling-metabolic flux-inflammatory output (136)

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