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The startups founding researchers already tested a family of compounds structurally related to spermidine and demonstrated that the 1,8-diaminooctane (VL-004) molecule induced mitophagy and protected from oxidative stress more effectively than spermidine, which facilitated extension of the C
In addition, presence of high concentrations of polyunsaturated fatty acids in the brain enhances their peroxidation and generation of toxic products which further causes degeneration of the cells harboring them or in vicinity 22
Safety comes down to the peptide, dose, and medical history
Thats where some of the affordability concerns are coming from: large populations are potentially eligible to take these drugs, and we cant pay for a lifetime supply for everyone. The researchers model suggested that even though the alternative weight-maintenance programs might be slightly less effective than long-term, full-dosage GLP-1RA use, the clinical benefits would only decrease slightly, while lifetime healthcare spending would decrease substantially