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196 When the Wnt/-catenin pathway is activated, it can reduce lipid ROS production in gastric cancer cells, and the -catenin/TCF4 transcription complex can directly bind to the GPX4 promoter region, enhancing its expression and thereby inhibiting cell ferroptosis

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Kruse M, Seki Y, Vuguin PM, Du XQ, Fiallo A, Glenn AS, Singer S, Breuhahn K, Katz EB, Charron MJ (2013) High-fat intake during pregnancy and lactation exacerbates high-fat diet-induced complications in male offspring in mice