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We estimated the incidence rates by 1000 person-years of the first SIS event, overall and for each group

Actinobacteria such as Eggerthella produce hydroxysteroid dehydrogenase (HSDH), which mediates the redox reaction of bile acids, producing various oxidized or isomeric bile acids, promoting Treg cell differentiation, inhibiting Th17 expansion, and maintaining intestinal immune tolerance and homeostasis 146

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