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In vitro experiments using a Bcl-2 inhibitor and adeno-associated virus (AAV)-mediated Bcl-2 knockdown confirmed that the protective effects of MOTS-c against NASH-induced mitochondrial dysfunction, inflammation, and fibrosis are dependent on Bcl-2 function

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PO 2 is significantly lower in the outer cortical proximal and distal convoluted tubules but not in the efferent arterioles of SHR when compared with normotensive Wistar Kyoto (WKY) rats 52

Research also examines BPC-157 effects on medial collateral ligament healing in animal models, with studies investigating both local and systemic administration routes