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The animals were separated depending on their phenotype (two obese or three lean animals per cage) at the age of 6 weeks in order to avoid microbial translocation through coprophagy

Tirzepatide may cause slightly more stomachrelated symptoms at higher doses

Reasons for discontinuation of obesity pharmacotherapy with semaglutide or tirzepatide in clinical practice

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Their balanced profiles may be advantageous for individuals seeking nutritional equilibrium without excessive caloric intake