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FDA staff had recommended against including emideltide, which is used for insomnia and opioid withdrawal, on the list in part because studies on its efficacy are limited and because there are alternative therapies available to treat those conditions

p53 tumour-suppressor caution Because FOXO4-DRI intervenes in the p53 pathway, which is critical for tumour suppression, there is theoretical concern that interfering with p53 dynamics might carry oncogenic risk

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Research progress on the pathogenesis of knee osteoarthritis