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The authors said they examined gastrointestinal adverse events associated with GLP-1 agonists used for weight loss in a clinical setting because randomized trials evaluating their efficacy were not designed to capture these events due to small sample sizes and short follow-up. For their study, researchers used a random sample of 16 million patients taken between 2006 and 2020 from the PharMetrics Plus, a health claims database with 93% of all U.S

Ozempic (semaglutide) is approved as a once-weekly GLP-1 receptor agonist that typically reaches steady-state levels within 4 to 5 weeks of consistent weekly dosing

Kanoski et al., 2011)

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