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Reaching the full dose matters more than reaching it quickly

(2014) showed that microglial NF-B is involved in the disease-like phenotypes progression in SOD1-G93A mice and suppression of NF-B reduces proinflammatory microglial activation (Frakes et al., 2014)

(2016) Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes. Medicine (Baltimore)

Additionally, some studies observed alterations in other immune cell populations, including reduced numbers of monocytes, CD8+ cells, and dendritic cells, and increased percentages of total lymphocytes and B cells (30)

This is one reason the middle third is safer than the upper third