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GHK-Cu is a naturally occurring copper-binding tripeptide (Gly-His-Lys) shown in laboratory and small clinical studies to support collagen synthesis, wound healing and antioxidant defenses

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[129, 142,143,144], a recent meta-analysis was unable to definitively establish a significant connection between overall vitamin and mineral deficiencies and fatigue in patients with ME/CFS [145], although some uncertainty about the role of vitamin E deficiency persists [146]