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Oral delivery of therapeutic peptides and proteins: technology landscape of lipid-based nanocarriers

doi: 10.1016/j.amjmed.2019.03.001 4

Moreover, downregulation of p/CIP and SRC-1 was found to enhance insulin sensitivity and increase glucose uptake in both regular and high fat diet-fed p/CIP and SRC-1 double knockout (DKO) mice, 336 indicating that targeting these diverse co-activators, is a promising pharmacological target for treatment of both type 2 diabetes and obesity

It acts as a non-selective agonist at melanocortin receptors MC1R, MC3R, MC4R, and MC5R with higher potency and metabolic stability than native -MSH

This research is preclinical, conducted in laboratory models rather than human endometriosis tissue