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Local aggressive behavior, rapid expansible growth, recurrence and malignant transformation were sometimes reported in literature [4, 22,23,24]

At the same time, there was a progressive increase in the prevalence of infection acquired by IDU, a decrease in transfusion-associated infections and an increase in the percentage of immigrants

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Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)