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Ligand-based virtual screening Ligand-based virtual screening (LBVS) was performed to identify small-molecule candidates with physicochemical, structural, or pharmacophoric similarity to known GLP-1R agonists

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A state of relative glucose intolerance develops when EGFR is deleted from -cells, suggesting a direct link to insulin secretion and a diminished level of baseline cell proliferation, consistent with previous work 8

The ratio of beta to alpha-2 receptors determines how readily a fat depot releases stored energy