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L-carnitine supplementation has been studied in sarcopenia, in liver diseases, in heart failure, in kidney diseases and in neurological diseases

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Although gastrointestinal intolerance is often most pronounced during early dose escalation and may attenuate over time, substantial inter-individual variability persists, highlighting the gap between therapeutic efficacy and real-world acceptability (4)

This review provides a comprehensive overview of the design, engineering, and surface functionalization of nanoparticles, highlighting their physicochemical properties, formulation strategies, and mechanisms governing stability, encapsulation efficiency, and controlled release

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