10.1073/pnas.91.18.8378 [DOI] [PMC free article] [PubMed] Nehlig A (2018) Interindividual Differences in Caffeine Metabolism and factors driving caffeine consumption
Guildford, n.d
Dosing Protocols Retatrutide (existing protocol) Maintain your current titration: Standard: 0.25mg 0.5mg 1mg 2mg 3mg (weekly increases) Most users stabilize between 1-3mg weekly No need to adjust Reta dose when adding Tesamorelin or MOTS-C Tesamorelin Starting dose: 1mg daily Maintenance dose: 2mg daily Timing: Evening, before bed (aligns with natural GH pulsatility) Injection: SubQ, abdomen or thigh Cycle length: 12 weeks on, 4 weeks off (standard) MOTS-C Option A (daily): 500mcg-1mg daily, morning Option B (pulsed): 5mg 2-3x weekly Timing: Morning preferred (aligns with metabolic activity) Injection: SubQ, any site Cycle length: 8-12 weeks on, 4 weeks off (receptor sensitivity consideration) Daily Schedule Example This schedule keeps compounds separated and aligns with natural physiology (MOTS-C with daytime metabolic activity, Tesamorelin with nighttime GH pulsing)
Xie C, Wang X, Jones KL et al (2020) Role of endogenous glucagon-like peptide-1 enhanced by vildagliptin in the glycaemic and energy expenditure responses to intraduodenal fat infusion in type 2 diabetes
With DPP4 inhibitor as a referent comparator, the estimates for different GLP1 receptor agonists numerically differed, but heterogeneity was not statistically significant ( p = 0.641)
