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Food and Drug Administration (FDA), European Medicines Agency (EMA), Pharmaceuticals and Medical Devices Agency (PMDA, Japan), Therapeutic Goods Administration (TGA, Australia), Health Canada, and Medsafe (New Zealand)

Together with the EXSCEL trials shorter follow-up duration, this could have attenuated the significance in the study outcome

Aronne said the dual-action approach of tirzepatide is likely the reason for its stronger results

"In patients with obesity who were prescribed semaglutide or liraglutide, we found that long-term weight reduction varied significantly based on the medication's active agent, treatment indication, dosage and persistence with the medication," said Hamlet Gasoyan, lead author of the study, in a statement

By modulating both insulin and glucagon, Ozempic helps maintain more stable blood sugar levels throughout the day