Unlike B12 deficiency, which produces recognisable neurological and haematological symptoms, excess vitamin B12 typically remains asymptomatic and is discovered incidentally during routine blood tests
This provides a pool of healthy cells that can readily take the place of those that are worn or damaged, leading to improved tissue function and decreasing the effects of aging
Figure 7 The disulfide and carba analogues examined demonstrated a relative high stability against proteolysis by metallopeptidases, despite the similarities in the N-terminal to oxytocin 35 and vasopressin 36 that both serve as substrates to IRAP (Alescio-Lautier et al., 2000
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Future research applications will likely expand to include investigation of senescence heterogeneity, tissue-specific senescent cell populations, and the development of personalized approaches to senolytic intervention based on individual senescent cell burden and characteristics
