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Plant profile, phytochemistry and pharmacology of Asparagus racemosus (Shatavari): A review

Similarly, we also found that the expression of GLP-1R was lower in knee cartilage tissues with OA induced by the administration of monoiodoacetate compared with the control group, which suggests a potential and crucial role of GLP-1R in OA development

Moreover, the use of drugs affecting mitochondria, where more than one-half of all ROS are generated, represents a suitable approach to induce oxidative stress and PCD in cancer cells 109 : gamitrinib, an inhibitor of heat shock protein 90 (HSP90), induces a dramatic collapse of mitochondria in prostate cancer cells 110 , while ARQ 501 (a quinone derivative) and STA-4783 (a copper chelator) increase ROS through leakage in the electron transport chain and have beneficial effects in patients with solid tumors and pancreatic adenocarcinoma 111

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As illustrated in Figure 1, activation of the cAMP/PKA/CREB axis promotes the differentiation of white adipocytes into thermogenic-like adipocytes and enhances brown adipose tissue activity, contributing to lipid metabolism regulation and energy balance 8