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Figure 2 When the components of the major adverse cardiovascular events were analyzed separately, increased levels of TMAO remained significantly associated with an increased risk of death (hazard ratio, 3.37

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This is notable because PHGDH and PSAT1 are heavily lactoylated and LGSH inhibits PHGDH activity (35

10.1016/j.cmet.2014.10.006 [DOI] [PMC free article] [PubMed] [Google Scholar] Koeth R