Initially identified as a CRY1-interacting protein in a high-throughput yeast two-hybrid screen (Rual et al., 2005), TRAF2 was later shown to bind directly to BMAL1, reducing its abundance without affecting CRY1 levels ( TRAF2 overexpression enhances BMAL1 ubiquitination and proteasomal degradation, thereby attenuating E-box-mediated transcription and dampening PER1 oscillations ( 4.1.18 UBE3A UBE3A, an E3 ubiquitin ligase previously implicated in Angelman syndrome and HPV-related tumorigenesis, has recently emerged as a conserved regulator of the circadian clock through its post-translational control of BMAL1 stability (Gossan et al., 2014
Lee HJ, Jung YH, Choi GE, Kim JS, Chae CW, Lim JR, et al
Nat Med 18:11121117
doi: 10.3389/fvets.2016.00095 43 QinYAngeliniLLChaiY
However, Cd-induced apoptosis in the kidney was blocked by RJ pretreatment (Fig