These limitations suggest directions for future improvements, such as combining single-cell sequencing technologies to screen differential gene expression in NHPs and carry out in vivo validations in rodents (Figure 3)
The same cell health tools you rely on in 2D are validated for 3D so your protocols, your data, and your confidence carry over
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Thus, during obesity, adipose tissue is distinguished by increased fibrosis, macrophage infiltration, a pro-inflammatory phenotype, leading to the appearance of insulin resistance through the release of free fatty acids, pro-inflammatory cytokines and adipokines