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In SMA, individuals lack a working copy of the SMN1 gene, and the ASOs are used to facilitate proper splicing of the SMN2 gene through inducing the inclusion of exon 7ultimately rescuing the expression of the SMN protein within in vitro mammalian cell models [91] In 2016, the FDA authorized the use of Spinraza, the first drug-based therapy for SMA [93]

Serrao providing guidance and monitoring throughout the treatment

Other side effects of testosterone replacement therapy include fluid retention, increased red cell count, and cholesterol changes.

Br J Anesth 52:367369 Aziz Q, Thompson DG (1998) Brain-gut axis in health and disease