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The target genes of p53 involve the canonical ferroptosis pathway of GSH metabolism (e.g., SLC7A11), iron metabolism (TfR1 and SLC25A28), lipid metabolism, ROS generation, several oxidation/reduction related proteins, and the non-canonical ferroptosis pathway (66, 67)

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In very select, treatment-resistant cases, deep brain stimulation (targeting specific regions of the thalamus) or motor cortex stimulation (placing electrodes on the surface of the brain over the motor cortex) has been investigated as a neuromodulation option

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Xiao Y, Zhao J, Zhang H, Zhai Q, Chen W