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This process can lead to the formation of a large vascular network, which allows for the regeneration of tissue

Notably, the ferroptosis inhibitor Ferrostatin-1 exacerbated CGAs toxicity, while the inducer Erastin attenuated it (Supplementary Figure S2C), suggesting that the profound iron deficiency we describe disrupts fundamental metabolism in a manner distinct from, and prior to, the execution of classical ferroptosisa pathway CGA has been shown to inhibit in other contexts via Nrf2/GPX4 activation (Yang et al., 2025)

For best results, use consistently for several months as collagen remodeling takes time

However, variations in assay methods, extraction solvents, and growing conditions often influence reported results [61] (Figure 11)

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