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The NLRP3 inflammasome stimulation by sUA is accompanied by cellular redox state changes, increasing in mitochondria area and mitochondrial ROS production

where they have enriched monocytes from healthy volunteers to generate the functional genomics datasets reanalyzed herein ( Cell Culture Monocytes were cultured in complete media consisting of Dulbeccos Modified Eagle Medium containing high glucose and sodium pyruvate (ThermoFisher Scientific) with 10% heat-inactivated fetal bovine serum (Wisent BioProducts) and 100U/mL penicillin/streptomycin (Corning)

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For statistical comparisons, two-tailed Students t-tests were employed for two-group comparisons, while one-way or two-way ANOVA with Bonferroni correction was used for comparisons involving three or more groups

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