Breast cancer screening Women with a personal or family history of hormone-sensitive cancers should discuss GLP-1 use with their oncologist
Support healthy levels with B vitamins (especially B6, B12 & folate)
They tend to upregulate the pro-apoptotic protein Bax and inhibit the anti-apoptotic protein Bcl-2, altering the Bax/Bcl-2 ratio to promote the release of cytochrome c, which in turn activates downstream apoptosis-executing proteins such as caspase-3 and caspase-9 ( 3.1.3 Inhibition of tumor microenvironment and angiogenesis Polyphenols also exert anticancer effects by remodeling the tumor microenvironment
This section synthesizes evidence on the systemic effects of metformin, sodiumglucose cotransporter 2 inhibitors (SGLT-2Is), GLP-1RAs, nonsteroidal mineralocorticoid receptor antagonists (ns-MRAs), and dual incretin agonists across organ systems
Studies have used MT-II alongside MC4R-selective agonists and MC4R knockout models to attribute the anorectic component of MT-IIs biology specifically to MC4R rather than MC3R activation
