SURMOUNT-1 Trial (New England Journal of Medicine, 2022) Randomized, double-blind, placebo-controlled 2,539 participants 72 weeks NCT04184622 Tirzepatide 5 mg -16.0% Mean body weight reduction Tirzepatide 10 mg -21.4% Mean body weight reduction Tirzepatide 15 mg -22.5% Mean body weight reduction Placebo group: -2.4% All results statistically significant (p 27 with Comorbidities Overweight or obese patients (Indian cutoff BMI 23+ with risk factors) seeking significant, sustained weight loss
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**Patients without diabetes and with BMI 30, or BMI 27 plus a weight-related condition, lost an average of 20% of their body weight by 1 year in a 72-week trial studying the highest maintenance dose of Zepbound (15 mg), when paired with diet and exercise changes (compared to 3% with diet and exercise alone)
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Potential vision problems linked to Ozempic use: Temporary issues: Blurred vision Difficulty focusing Increased sensitivity to light Potentially permanent damage: Worsening of diabetic retinopathy Development of macular edema Optic nerve damage Exacerbation of pre-existing conditions: Acceleration of diabetic eye disease Potential worsening of glaucoma or other chronic eye conditions If youve experienced any vision changes while using Ozempic, its crucial to seek immediate medical attention
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