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Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis

Traditional hormonal avenues of treatment are also explored with repurposed medicines, like progestogens (two), GnRH antagonists (one) and other gynaecological medications such as fezolinetant, marketed for treatment of menopause related vasomotor symptoms (in Phase II), and three drugs initially developed for treating breast cancer (tamoxifen, raloxifene, letrozole)

There is abundant evidence that oxidant stress may play an important role in the modification of vascular thromboresistance in moderate hyperhomocysteinemia

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Together, this framework aims to guide mechanistic studies and accelerate the development of clinically actionable lactylation-directed interventions