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These landmark investigations employed rigorous double-blind, placebo-controlled methodology eliminating confounding variables

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"You can look at a Sunday roast, with gravy and beef and perfect Yorkshire puddings, and you think: 'I'll just have a stick of celery instead.'" Clarkson went on to explain that he went to a clinic in London for blood and ultrasound tests before being prescribed the drug to prevent him from becoming diabetic

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They further noted that GLP-1 RA use was associated with higher risks of gallbladder or biliary diseases at higher doses (RR, 1.56) compared with lower doses (RR, 0.99) and with longer duration of use (RR, 1.40) compared with shorter duration (RR, 0.79)