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Inside that overarching trial, Lilly nested two "basket" sub-studies to test whether the weight loss would carry specific obesity comorbidities with it: Knee osteoarthritis basket: 574 participants with symptomatic knee OA Obstructive sleep apnea basket: 243 participants with moderate-to-severe OSA The design matters

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Knocked down by no validated PHQ depression instrument, no substance-use or alcohol panel, and only a single-question diet/exercise depth

Women tend to lose a higher percentage of their starting body weight, and that edge grows wider as total weight loss climbs