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Codon adaptation-based control of protein expression in C

TRIUMPH-1 and TRIUMPH-2 are the pivotal trials

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X 31 is absent or is selected from the group consisting of PX 32 X 33 X 34 R 2 (SEQ ID NO:4), PX 32 X 33 X 34 X 35 X 36 X 37 X 38 X 39 R 2 (SEQ ID NO:5), PX 32 X 33 X 34 X 35 X 36 X 37 X 38 X 39 X 40 R 2 (SEQ ID NO:6), K[(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl) 2 -(-Glu)-CO(CH 2 ) q CO 2 H] X 32 X 33 X 34 R 2 (SEQ ID NO:7), K[(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl) 2 -(-Glu)-CO(CH 2 ) q CO 2 H] X 32 X 33 X 34 X 35 X 36 X 37 X 38 X 39 R 2 (SEQ ID NO:8), and K[(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl) 2 -(-Glu)-CO(CH 2 ) q CO 2 H] X 32 X 33 X 34 X 35 X 36 X 37 X 38 X 39 X 40 R 2 (SEQ ID NO:9)