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Mutagenesis Dihydroergotamine mesylate was clastogenic in two in vitro chromosomal aberration assays, the V79 Chinese hamster cell assay with metabolic activation and the cultured human peripheral blood lymphocyte assay

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6 One placebo-controlled trial evaluated 1,400mg administered three times per week for four weeks in patients with Parkinsons disease

Markers of neuroplasticity including dendritic spine density and synaptic protein expression remain elevated for 10-14 days following administration, meaning the neuroplastic processes initiated by earlier doses continue developing during the interruption