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Healthcare professionals should provide individualised advice based on patient-specific factors including: Body weight and composition (larger individuals generally require more fluid) Concurrent medications (particularly diuretics or other agents affecting fluid balance) Comorbidities (such as chronic kidney disease or heart failure, which may require fluid restriction) Physical activity levels (increased activity necessitates additional fluid replacement) Climate and environmental factors (hot weather increases insensible losses) Patients should be encouraged to monitor their urine colour as a simple indicator of hydration status, aiming for pale straw-coloured urine throughout the day

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Niacinamide blocks melanin transfer

PMID 21631324