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The conversion of ribonucleotides to deoxyribonucleotides, through the action of ribonucleotide reductase, requires NADPH, therefore any rapidly proliferating cell needs large quantities of NADPH

doi: 10.1016/j.ccell.2023.06.011 139 ZhouXChenCZhongYNZhaoFHaoZXuYet al

[18] Lactation studies demonstrate that maternal injections modestly elevate breast-milk B12 concentrations without adverse infant outcomes, supporting compatibility with breastfeeding while underscoring the need for maternal repletion to prevent neonatal deficiency