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4 Discussion Obesity is a highly prevalent, chronic, relapsing disease requiring long-term management ( via the incretin pathway, stimulating insulin and inhibiting glucagon secretion in a glucose-dependent manner, leading to lower blood glucose levels with low risk for hypoglycaemia ( To determine the role of semaglutide in obese mice, we performed intraperitoneally injections of semaglutide to HFD-induced obese mice, whereas the NCD and HFD groups were treated with saline for 12 weeks

Orally administrated pterostilbene attenuates acute cerebral ischemia-reperfusion injury in a dose- and time-dependent manner in mice

Especially those reducing pathogenic responses have been tested for therapeutic purposes in clinical trials

It depends on baseline status and goals

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