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11:905-914 [PMC free article: PMC10957483] [PubMed: 37865101] 235
REDEFINE 1 was a 68-week, double-blind, placebo- and active-controlled efficacy and safety phase 3 trial of once-weekly CagriSema, cagrilintide 2.4 mg and semaglutide 2.4 mg versus placebo in 3,417 adults with obesity or overweight with one or more comorbidities and without type 2 diabetes
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In two independent studies, supplementation of Lactobacillus paracasei or Bifidobacterium bifidum to healthy individuals increased fecal butyrate levels (92, 93), indicating that traditional probiotics may modulate the activity of butyrate producers
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