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The peptide activates transforming growth factor-beta (TGF-) signaling cascades, leading to enhanced collagen I and III synthesis through increased procollagen C-proteinase activity

Acting on two complementary points of the same axis, the two compounds are studied together for a larger, cleaner GH pulse than either produces alone with Ipamorelin chosen specifically because it raises GH with minimal spillover onto cortisol (the stress hormone) or prolactin

doi: 10.1136/adc.2005.091637 48 PampolsT

Preclinical studies may explore its influence on collagen synthesis in fibroblasts, proliferation of chondrocytes, and the maintenance of bone mineral density in models of osteoporosis, providing insights into tissue regeneration and age-related decline

Moi et al, 1994)