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10.1902/jop.1991.62.2.147 J

FBCM is currently considered to be the most common cause of vitamin B12 deficiency, caused by impairment in the release of the vitamin from food, commonly because of conditions such as gastritis, achlorhydria, gastrectomy, use of antacids, or proton pump inhibitors (PPIs), gastric atrophy in the elderly, and Helicobacter pylori infection (63, 74)

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Bottom panel: NK cytotoxicity was assessed using 51 Cr-labeled human K562 cells as the target and measuring the percent of target cells lysed after incubation with lymphocytes for 4 h at 37 C