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Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)

PMID: 27 SalihKJ

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Elevated ROS levels activate the mitochondrial permeability transition pore (mPTP), further disrupting mitochondrial function and creating a cycle of oxidative stress [23]