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As possible explanations for their results, the authors suggest an apparent selectivity of the fractions with higher alkaloid levels for some tumour lineages, low water solubility of isolated alkaloids and issues regarding the IC 50 measures

The liposomal glutathione benefits extend beyond basic antioxidant protection

Phosphoribosyl pyrophosphate synthetase 1 (PRPS1), the key enzyme of the de novo nucleotide synthesis pathway, is O -GlcNAcylated by O -GlcNAc transferase (OGT), which triggers PRPS1 hexamer formation and relieves nucleotide product-mediated feedback inhibition, thereby boosting PRPS1 activity

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