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Melanin pigment is often present in the cytoplasm of keratinocytes at all layers of the epidermis, including the stratum granulosum and corneum (not to be confused with melanocytes)

As well, in real-world scenarios, such as described by Brindisi et al, it is mentioned a reduction in pleasure and taste perception in overweight and people with obesity with poor type 2 diabetes control, probably by lowering the detection threshold of sweet flavors, becoming more sensitive to them, resulting in aversion for this flavor (175)

starting with lower doses can mitigate these effects

b, c AICAR (A, 250 mg/kg) or vehicle alone (PBS) were injected i.p