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The analysis of phylogenetic tree was carried out by MEGA X [44], and depicted by EvolView online tools [45]

Ketone bodies increase glomerular filtration rate in normal man and in patients with type 1 (insulin-dependent) diabetes mellitus

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It could be speculated that this increased discontinuation rate vs all comparators, including GLP-1 RAs, may be possibly attributed to the severity of gastrointestinal adverse events experienced with tirzepatide 15 mg, considering that the incidence of gastrointestinal adverse events was similar between tirzepatide and GLP-1 RAs