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Mechanism of Action Retatrutide engages three complementary metabolic pathways simultaneously, producing additive effects that exceed what any single receptor target can achieve alone: Why glucagon agonism matters Counter-intuitively, activating the glucagon receptor increases energy expenditure without causing the hyperglycaemia seen in isolation, because the GLP-1 and GIP components simultaneously drive insulin secretion

Enhances Fat Metabolism: L-Carnitine aids in the transport of fats for energy production

10.1002/ajmg.c.20007

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Peer review Peer review information Nature Reviews Urology thanks the anonymous reviewers for their contribution to the peer review of this work