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The acute hemolysis, that is the only common clinical manifestation associated with pathogenic variants in the G6PD gene, can rapidly be compensated for and thus, may remain undetectable

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Thus, we determined ER-stress response genes Xbp1 and the ER chaperone heat shock 70 kDa protein 5 (HSPA5, previously known as immunoglobulin heavy chain binding protein [BIP]), inflammation-responsive genes IL6 and IL1, and hypoxia-responsive genes hypoxia-inducible transcription factor 1 (HIF1) and GAPDH

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Population differences Clinical trial participants are carefully selected