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It is a naturally occurring molecule
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Therefore, riboflavin deficiency will lead to the downregulation of GSH and oxidative stress, which is the predominant cause for reduced osteogenic capacities of BMSCs and enhanced osteoclastic potentials of osteoclast precursors [54, 55], finally leading to net bone loss
These differences in affinity of APx and CAT suggest that APx is responsible for the fine tuning of ROS concentrations for signaling, whereas CAT might remove the excess ROS as was suggested after metal exposure in Arabidopsis thaliana [90]
Although water-referenced neurochemical concentrations are considered by some as the gold standard approach for MRS, there are numerous technical challenges and assumptions that can limit the utility of water-referenced measurements
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