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doi: 10.1093/nar/gki248

The MHRA has previously issued safety communications regarding unlicensed injectable preparations sometimes marketed as 'skinny jabs' or lipotropic injections circulating in the UK market, highlighting risks related to sterility, dosing accuracy, and undisclosed ingredients

Another significant area of investigation is wound healing and angiogenesis

- Enhanced Mood:Supports mental health by aiding neurotransmitter production

From a pharmacological safety perspective, the adverse effect profile of retatrutide based on Phase 1 and Phase 2 clinical trial data (including the NEJM 2023 Phase 2 trial) includes: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (the most commonly reported side effects in trial participants) Injection site reactions: Redness, swelling, or discomfort at the injection site Cardiovascular effects: Increases in heart rate have been observed in trial participants [21] [22] Hypoglycaemia: Particularly relevant in individuals with diabetes or those taking insulin, sulfonylureas, or other glucose-lowering agents Potential thyroid effects: GLP-1 receptor agonists have been associated with thyroid C-cell changes in rodent studies