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Yet another aspect of the invention is to provide a method for increasing the reliability of therapy for sexual dysfunction, such as with patients that are responsive to a PDE-5 inhibitor less than 100% of the time, such as less than about 50% of the time, by multiple agent therapy with a PDE-5 inhibitor and a melanocortin receptor agonist such as PT-141

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Hence, an important issue was the extent to which APAP toxicity might vary within the population

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